Treatment of Lung Cancer Using Magnetic Nanoparticles Hyperthermia: Simulation-Based Study and Cardiac Thermal Safety

Document Type : Original Research Paper

Authors

1 Department of Physics, Faculty of Sciences, Bu-Ali Sina University, Hamedan

2 Physics Department, Bu-Ali Sina University, Hamedan 65174, I.R. Iran

3 Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan

4 Department of Medical Physics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan

10.22111/cnmst.2025.52359.1264

Abstract

Magnetic hyperthermia is an emerging, minimally invasive modality for targeted cancer therapy, utilizing magnetic nanoparticles (MNPs) to induce localized heating within tumors. This study presents a comprehensive simulation-based analysis of magnetic hyperthermia applied to lung cancer. A two-dimensional axisymmetric finite element model was developed, incorporating key anatomical components tumor, air cavity, muscle, bone, skin to evaluate spatial thermal profiles under physiological respiratory dynamics. Magnetite (Fe₃O₄) nanoparticles (19 nm) were subjected to an alternating magnetic field (AMF) at 300 kHz and current intensity 300 A to induce localized heating through Néel and Brownian relaxation mechanisms. The model assessed thermal propagation during inhalation and exhalation, targeting tumor ablation temperatures (42–46 °C). Simulation results confirm the feasibility and thermal safety of MNP-assisted magnetic hyperthermia for lung cancer. These findings offer a clinically relevant framework for optimizing treatment planning and nanoparticle design. The novelty of this study lies in the development of a physiologically accurate finite element simulation that incorporates respiratory dynamics. This integrated approach, combining porous media modeling with thermal distribution analysis under dynamic breathing phases, offers new insights into optimizing safe and effective hyperthermia treatments for thoracic malignancies.

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Challenges in Nano and Micro Scale Science and Technology
Volume 12, Issue 2
September 2024
Pages 60-65

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