Exploring Magnetic Chitosan Functionalized with POCl2-x as a Nanocatalyst for Amino Alcohol Synthesis from Azido Alcohol

Document Type : Original Research Paper

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Islamic Azad University of Marvdasht

Abstract

β-Amino alcohols play a crucial role in natural product synthesis, especially in the pharmaceutical industry, serving as important intermediates in advancing of medicinal chemistry and drug discovery. This study presents a new method for synthesizing β-amino alcohols using an eco-friendly nanocomposite Fe3O4@SiO2@Chitosan@POCl2-x with an average size of 157nm, achieving rapid efficiency through the aminolysis of an azide compound in the presence of CH3CN-H2O (9:1) and heat (80°C), resulting in yields of 77-90%. The presence of chitosan enhances the catalyst's environmental friendliness and promotes the smooth conversion of azides into amino alcohols. This conversion process involves mechanisms such as water incorporation and proton transfer, facilitated by the surface hydroxyl and amine groups on the nanocomposite. The catalyst demonstrates exceptional performance under mild conditions, promising high yields and highlighting its significance in organic synthesis. Furthermore, the catalyst's magnetic recoverability, diverse composition, and ability to facilitate efficient and clean reactions underscore its indispensable role in amino alcohol synthesis.

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